abstract：:Somatosensory information from the limbs reaches the contralateral Primary Sensory Cortex (S1) with a delay of 23ms for finger, and 40ms for leg (somatosensory N20/N40). Upon arrival of this input in the cortex, motor evoked potentials (MEPs) elicited by Transcranial Magnetic Stimulation (TMS) are momentarily inhibite...

journal_title：Neuroscience

authors： Ruddy KL,Jaspers E,Keller M,Wenderoth N

更新日期：2016-10-01 00:00:00

abstract：:Abacus-based mental calculation (AMC) activates the frontoparietal areas largely overlapping with the working memory (WM) network. Given the critical role of WM in cognition, how to improve WM capability has attracted intensive attention in past years. However, it is still unclear whether WM could be enhanced by AMC t...

journal_title：Neuroscience

authors： Dong S,Wang C,Xie Y,Hu Y,Weng J,Chen F

更新日期：2016-09-22 00:00:00

abstract：:The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI) is a measure of sensorimotor gating which is a basic process whereby...

journal_title：Neuroscience

authors： Marks WN,Greba Q,Cain SM,Snutch TP,Howland JG

更新日期：2016-09-22 00:00:00

abstract：:Iron-overload can cause cognitive impairment due to blood-brain barrier (BBB) breakdown and brain mitochondrial dysfunction. Although deferiprone (DFP) has been shown to exert neuroprotection, the head-to-head comparison among iron chelators used clinically on brain iron-overload has not been investigated. Moreover, s...

journal_title：Neuroscience

authors： Sripetchwandee J,Wongjaikam S,Krintratun W,Chattipakorn N,Chattipakorn SC

更新日期：2016-09-22 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The underlying mechanisms of LID pathogenesis are still not fully unders...

journal_title：Neuroscience

authors： Klietz M,Keber U,Carlsson T,Chiu WH,Höglinger GU,Weihe E,Schäfer MK,Depboylu C

更新日期：2016-09-07 00:00:00

abstract：:Sigma-1 receptor (S1R) is a unique pluripotent modulator of living systems and has been reported to be associated with a number of neurological diseases including pathological pain. Intrathecal administration of S1R antagonists attenuates the pain behavior of rodents in both inflammatory and neuropathic pain models. H...

journal_title：Neuroscience

authors： Mavlyutov TA,Duellman T,Kim HT,Epstein ML,Leese C,Davletov BA,Yang J

更新日期：2016-09-07 00:00:00

abstract：:Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer's disease (AD). Non-invasive diagnostic methods are desirable to identify MCI for early therapeutic interventions. In this study, we proposed a support vector machine (SVM)-based method to discriminate between MCI patien...

journal_title：Neuroscience

authors： Long Z,Jing B,Yan H,Dong J,Liu H,Mo X,Han Y,Li H

更新日期：2016-09-07 00:00:00

abstract：:Hindbrain dorsal vagal complex A2 noradrenergic signaling represses the pre-ovulatory luteinizing hormone (LH) surge in response to energy deficiency. Insulin-induced hypoglycemia augments A2 neuron adenosine 5'-monophosphate-activated protein kinase (AMPK) activity and estrogen receptor-beta (ERβ) expression, coincid...

journal_title：Neuroscience

authors： Briski KP,Shrestha PK

更新日期：2016-09-07 00:00:00

abstract：:Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo studies in humans. Because of the increasing importance of mitochondrial pathogenetic hypothesis of Depression, in this study the effects of sub-chronic treatment (21days) with desipramine (15mg/kg) and fluoxetine (10mg/kg) were e...

journal_title：Neuroscience

authors： Villa RF,Ferrari F,Gorini A,Brunello N,Tascedda F

更新日期：2016-08-25 00:00:00

abstract：:Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (Aβ) peptides and intracellular tau aggregates. The plaques are surrounded by microglia, the brain's resident immune cells, which likely participate in the clearanc...

journal_title：Neuroscience

authors： Gyoneva S,Swanger SA,Zhang J,Weinshenker D,Traynelis SF

更新日期：2016-08-25 00:00:00

abstract：:Coping skills are essential in determining the outcomes of aversive life events. Our research was aimed to elucidate the molecular underpinnings of different coping styles in two inbred mouse strains, C57BL/6J and SWR/J. We compared the influence of a preceding stressor (0.5h of restraint) on behavioral and gene expre...

journal_title：Neuroscience

authors： Szklarczyk K,Korostynski M,Golda S,Piechota M,Ficek J,Przewlocki R

更新日期：2016-08-25 00:00:00

abstract：:Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension. The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to...

journal_title：Neuroscience

authors： Wang HW,Huang BS,White RA,Chen A,Ahmad M,Leenen FH

更新日期：2016-08-04 00:00:00

abstract：:Autophagy plays an essential role in neurodevelopment, axonal guidance, neuropathic pain remission, and neuronal survival. Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway can induce the occurrence of autophagy. In this study, we initially detected the effect of probucol on autophagy after spinal ...

journal_title：Neuroscience

authors： Zhou Z,Chen S,Zhao H,Wang C,Gao K,Guo Y,Shen Z,Wang Y,Wang H,Mei X

更新日期：2016-08-04 00:00:00

abstract：:Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among h...

journal_title：Neuroscience

authors： Mao Y,Sang N,Wang Y,Hou X,Huang H,Wei D,Zhang J,Qiu J

更新日期：2016-07-22 00:00:00

abstract：:Several genetic mutations affecting the development and function of mammalian hair cells have been shown to cause deafness but not vestibular defects, most likely because vestibular deficits are sometimes centrally compensated. The study of hair cell physiology is thus a powerful direct approach to ascertain the funct...

journal_title：Neuroscience

authors： Tavazzani E,Spaiardi P,Zampini V,Contini D,Manca M,Russo G,Prigioni I,Marcotti W,Masetto S

更新日期：2016-07-22 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

journal_title：Neuroscience

authors： Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

更新日期：2016-07-22 00:00:00

abstract：:Beta-amyloid (Aβ) deposition and neuroinflammation are involved in Alzheimer's disease (AD)-type neurodegeneration with cognitive deficits. Phosphodiesterase-5 (PDE5) inhibitors have recently been studied as a potential target for cognitive enhancement by reducing inflammatory responses and Aβ levels. The present stud...

journal_title：Neuroscience

authors： Yin C,Deng Y,Gao J,Li X,Liu Y,Gong Q

更新日期：2016-07-22 00:00:00

abstract：:Regret and relief are associated with counterfactual thinking and are sensitive to various social contexts. In the present fMRI study, we investigated the neural basis for regret and relief and how social context (following vs. not following advice) modulates them by employing a sequential risk-taking task. Participan...

journal_title：Neuroscience

authors： Liu Z,Li L,Zheng L,Hu Z,Roberts ID,Guo X,Yang G

更新日期：2016-07-07 00:00:00

abstract：:The vertebrate blood-brain barrier (BBB) creates an obstacle for central nervous system-related drug delivery. Claudin-5 (Cldn5), expressed in large quantities in BBB, plays a vital role in restricting BBB permeability. The C-terminal domain of Clostridium perfringens enterotoxin (cCPE) has been verified as binding to...

journal_title：Neuroscience

authors： Liao Z,Yang Z,Piontek A,Eichner M,Krause G,Li L,Piontek J,Zhang J

更新日期：2016-07-07 00:00:00

abstract：:Neuronal activity associated with visual processing of an unfamiliar face gradually diminishes when it is viewed repeatedly. This process, known as repetition suppression (RS), is involved in the acquisition of familiarity. Current models suggest that RS results from interactions between visual information processing ...

journal_title：Neuroscience

authors： Lafontaine MP,Lacourse K,Lina JM,McIntosh AR,Gosselin F,Théoret H,Lippé S

更新日期：2016-06-21 00:00:00

abstract：:A plethora of studies have indicated that enriched environment (EE) paradigm provokes plastic and morphological changes in astrocytes with accompanying increments of their density and positively affects the behavior of rodents. We also previously documented that EE could be employed to preclude several behavioral abno...

journal_title：Neuroscience

authors： Rahati M,Nozari M,Eslami H,Shabani M,Basiri M

更新日期：2016-06-21 00:00:00

abstract：:In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...

journal_title：Neuroscience

authors： Carvalho JC,Lisboa PC,de Oliveira E,Peixoto-Silva N,Pinheiro CR,Fraga MC,Claudio-Neto S,Franci CR,Manhães AC,Moura EG

更新日期：2016-06-14 00:00:00

abstract：:Alzheimer's Disease is the leading neurodegenerative cause of dementia. The pathogenesis is not clearly understood yet, is believed to be the complex interaction between genetic and environmental factors. Consequently vascular risk factors and Apolipoprotein E genotyping are increasingly gaining importance. This study...

journal_title：Neuroscience

authors： Panpalli Ates M,Karaman Y,Guntekin S,Ergun MA

更新日期：2016-06-14 00:00:00

abstract：:Neural activity during early development is known to alter innervation pathways in the central and peripheral nervous systems. We sought to examine how reduced sound-induced sensory activity in the cochlea affected the consolidation of glutamatergic synapses between inner hair cells (IHC) and the primary auditory neur...

journal_title：Neuroscience

authors： Barclay M,Constable R,James NR,Thorne PR,Montgomery JM

更新日期：2016-06-14 00:00:00

abstract：:Motor, sensory, and autonomic abnormalities are reported for toll-like receptor 9 (TLR9) knock-out (KO) mice. However, a physiological role of TLR9 in the nervous system is largely unknown. Since altered synaptic transmission can contribute to sensory and motor abnormalities, we evaluated neuromuscular junction (NMJ) ...

journal_title：Neuroscience

authors： Patel V,Patel AM,McArdle JJ

更新日期：2016-06-02 00:00:00

abstract：:Diversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labor and a subdivision into castes based on physiology and behavior. Damaraland mole...

journal_title：Neuroscience

authors： Oosthuizen MK,Amrein I

更新日期：2016-06-02 00:00:00

abstract：:Aberrant activation of the developing immune system can have long-term negative consequences on cognition and behavior. Teratogens, such as alcohol, activate microglia, the brain's resident immune cells, which could contribute to the lifelong deficits in learning and memory observed in humans with Fetal Alcohol Spectr...

journal_title：Neuroscience

authors： Boschen KE,Ruggiero MJ,Klintsova AY

更新日期：2016-06-02 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the accumulation and deposition of plaques of amyloid-β (Aβ) peptide in the brain. Growing epidemiological and experimental studies have shown that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts neuroprotection against AD. However, the underlying mechanisms of the action rem...

journal_title：Neuroscience

authors： Guo YX,He LY,Zhang M,Wang F,Liu F,Peng WX

更新日期：2016-05-13 00:00:00

abstract：:GLE1 mutations cause lethal congenital contracture syndrome 1 (LCCS1), a severe autosomal recessive fetal motor neuron disease, and more recently have been associated with amyotrophic lateral sclerosis (ALS). The gene encodes a highly conserved protein with an essential role in mRNA export. The mechanism linking Gle1 ...

journal_title：Neuroscience

authors： Seytanoglu A,Alsomali NI,Valori CF,McGown A,Kim HR,Ning K,Ramesh T,Sharrack B,Wood JD,Azzouz M

更新日期：2016-05-13 00:00:00

abstract：:Multiple system atrophy (MSA) is a sporadic neurodegenerative disease. The major pathological hallmark of MSA is the accumulation of α-synuclein in oligodendrocytes. In contrast to Parkinson's disease no definitive familial etiology for MSA has been determined. Yet, there is a growing body of evidence that perturbatio...

journal_title：Neuroscience

authors： Mills JD,Ward M,Kim WS,Halliday GM,Janitz M

更新日期：2016-05-13 00:00:00

abstract：:Biases in facial expression recognition can be reduced successfully using feedback-based training tasks. Here we investigate with event-related potentials (ERPs) at which stages of stimulus processing emotion-related modulations are influenced by training. Categorization of subtle facial expressions (morphed from neut...

journal_title：Neuroscience

authors： Pollux PM

更新日期：2016-05-13 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is an established technique that can modulate excitability of the motor cortex and corticospinal tract, beyond the duration of the stimulation itself. More recently, a newer repetitive technique, known as I-wave periodicity TMS (iTMS) has been purported to show incre...

journal_title：Neuroscience

authors： Kidgell DJ,Mason J,Frazer A,Pearce AJ

更新日期：2016-05-13 00:00:00

abstract：:Animals change their biological activities depending on their nutritional state. Reproductive functions, including sexual behavior, are suppressed under low-energy conditions; however, the underlying neuronal mechanism is poorly understood. Neuropeptide Y (NPY) is an orexigenic molecule released in response to low-ene...

journal_title：Neuroscience

authors： Inaba A,Komori Y,Muroi Y,Kinoshita K,Ishii T

更新日期：2016-04-21 00:00:00

abstract：:κ opioid receptor agonists produce aversive effects in rodents, however the underlying mechanisms remain unclear. Activation of p38 mitogen-activated protein kinase (MAPK) has been discovered to play a critical role in the modulation of affective behaviors. The present study was undertaken to detect the possible invol...

journal_title：Neuroscience

authors： Zan GY,Wang Q,Wang YJ,Chen JC,Wu X,Yang CH,Chai JR,Li M,Liu Y,Hu XW,Shu XH,Liu JG

更新日期：2016-04-21 00:00:00

abstract：:It is well established that multisensory integration is a functional characteristic of the superior colliculus that disambiguates external stimuli and therefore reduces the reaction times toward simple audiovisual targets in space. However, in a condition where a complex audiovisual stimulus is used, such as the optic...

journal_title：Neuroscience

authors： Costa M,Piché M,Lepore F,Guillemot JP

更新日期：2016-04-21 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is an important complication following major surgery and general anesthesia in older patients. However, the etiology of POCD remains largely to be determined. It is unknown how surgical stress and psychological stress affect the postoperative learning and memory function in g...

journal_title：Neuroscience

authors： Zhang C,Li C,Xu Z,Zhao S,Li P,Cao J,Mi W

更新日期：2016-04-21 00:00:00

abstract：:Excitatory amino acid carrier 1 (EAAC1) is one important subtype of the excitatory amino acid transporters (EAATs), and its absence can increase the vulnerability to oxidative stress in neural tissue. Enhanced expression of EAAC1 can provide neuroprotection in multiple disorders, including ischemia and multiple sclero...

journal_title：Neuroscience

authors： Huang C,Yuan P,Wu J,Huang J

更新日期：2016-04-05 00:00:00

abstract：:Protection of substantia nigra (SN) dopaminergic (DA) neurons by neurotrophic factors (NTFs) is one of the promising strategies in Parkinson's disease (PD) therapy. A major clinical challenge for NTF-based therapy is that NTFs need to be delivered into the brain via invasive means, which often shows limited delivery e...

journal_title：Neuroscience

authors： Pang Y,Lin S,Wright C,Shen J,Carter K,Bhatt A,Fan LW

更新日期：2016-03-24 00:00:00

abstract：:Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities...

journal_title：Neuroscience

authors： Tao K,Ichikawa J,Matsuki N,Ikegaya Y,Koyama R

更新日期：2016-03-24 00:00:00

abstract：:Aquaporin-4 (AQP4), a water-selective membrane transport protein, is up-regulated in astrocytes in various inflammatory lesions, including Parkinson disease (PD). However, the exact functional roles of AQP4 in neuroinflammation remain unknown. In the present study, we investigated how AQP4 participates in the neuroinf...

journal_title：Neuroscience

authors： Sun H,Liang R,Yang B,Zhou Y,Liu M,Fang F,Ding J,Fan Y,Hu G

更新日期：2016-03-11 00:00:00